Views:25 Author:Site Editor Publish Time: 2017-03-22 Origin:Site
Effects of geniposide on diabetic vascular complications
Wu Shuguang, professor at Southern Medical University School of medicine and other research shows that the main component of traditional Chinese medicine Gardenia gardenia, in the anti diabetic vascular complications have a significant role. The study provides a scientific and effective basis for the treatment of diabetes mellitus in Chinese medicine, the results of the study published in the recently published Chinese Journal of pharmacology.
Diabetes mellitus (DM) is a kind of syndrome characterized by high blood glucose and stable change of intracellular environment, involving glucose, protein and lipid metabolism. Diabetic vascular complications are the most common chronic complications of diabetes, which are common in heart, brain, kidney and retina. Therefore, scholars at home and abroad are very concerned about the mechanism of diabetic vascular disease and the search for effective treatment.
Gardenia is a kind of traditional Chinese medicine, which has the effect of purging fire and removing heat, clearing heat and diuresis, cooling blood and removing blood stasis. Gardenia contains a variety of chemical components, pharmacological experiments show that, as the representative of the iridoid glycosides as the main active ingredients of Gardenia jasminoides Ellis, with the gallbladder, analgesic, liver protection, anti-cancer, anti-inflammatory effect. Previous studies showed that geniposide can play a role in lowering blood sugar in diabetic mice by inhibiting glycogen phosphorylase and glucose -6- phosphatase; aglycone of Geniposide can inhibit the inflammatory cytokine release of endothelium.
Endothelial cell dysfunction plays an important role in the process of diabetic vascular disease induced by high glucose, over expression of cell adhesion molecules and leukocyte adhesion to vascular endothelium is an early endothelial cell dysfunction. High blood sugar through a series of complex mechanism of induced expression of endothelial cells and release of inflammatory cytokines, chemokines, adhesion molecules, the circulating leukocyte and platelet adhesion to the endothelial cell surface, and then into the subendothelial, further damaged subendothelial tissue. Closely related to adhesion molecules released by endothelial cells including monocyte chemoattractant protein -1 (MCP-1), P- selectin (P-selectin), E- selectin (E-selectin), adhesion molecule -1 (VCAM-1) and intercellular adhesion molecule -1 (ICAM-1).
Wu Shuguang's research group has discussed the effect of geniposide on diabetic vascular complications from the perspective of whether it can inhibit the adhesion of endothelial cells induced by high glucose. The results show that the adhesion of Geniposide significantly inhibited high glucose induced human umbilical vein endothelial cells and mononuclear cell THP-1; inhibit E- in human umbilical vein endothelial cells induced by high glucose and expression of adhesion molecule -1; inhibit human umbilical vein endothelial cells induced by high glucose and oxygen free radicals generated by activation; inhibit human umbilical vein endothelial cell nuclear factor - high glucose induced B signaling pathway.